Fwd: Nature Reviews Immunology Contents December 2009 Volume 9 Number 12 pp 817-889

TABLE OF CONTENTS
December 2009 Volume 9 Number 12		Advertisement
Impact Factor 30.01 * Subscribe to Nature Reviews Immunology Recommend to your library	In this issue Research Highlights Reviews Perspectives Also this month Article Series: Tissue-specific immune responses  Featured article: Antigen presentation in the thymus for positive selection and central tolerance induction Ludger Klein, Maria Hinterberger, Gerald Wirnsberger & Bruno Kyewski	JUST WHAT YOU'D EXPECT FROM THE GLOBAL CENTRIFUGATION LEADER Beckman Coulter delivers powerful centrifuge solutions that keep you at the forefront of discovery. From intelligent centrifuge systems and versatile rotors to innovative labware and more, we offer unparalleled efficiency, productivity and safety in your lab. Learn what six decades of innovation can do for you.
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Nature Reprint Collection Immuno-epigenetics Epigenetic mechanisms are increasingly appreciated to have an important role in immune cell functional diversity and adaptability, and understanding these mechanisms holds considerable potential for revealing new opportunities to therapeutically modulate the immune response in a range of diseases. This special Collection brings together articles from Nature, Nature Immunology, Nature Reviews Immunology and Nature Reviews Drug Discovery that have contributed to advances and discussions in the field of immune cell epigenetics. Read the Collection online for FREE: www.nature.com/reprintcollections/gsk/immuno-epigenetics Produced with Support from: GlaxoSmithKline
From the editors p817 | doi:10.1038/nri2677 PDF
RESEARCH HIGHLIGHTS Top Mucosal immunology: Homing in on the friendliest of bacteria p818 | doi:10.1038/nri2679 PDF Innate immunity: HMGB proteins: universal sensors for nucleic acids p819 | doi:10.1038/nri2676 PDF IN BRIEF HIV | Cytokines | Regulatory T cells p819 | doi:10.1038/nri2683 PDF Immune synapses: TCR-CD3 recycling to the synapse p820 | doi:10.1038/nri2680 PDF Natural killer T cells: Switching on human NKT cells p820 | doi:10.1038/nri2681 PDF IN BRIEF Innate immunity | Transplantation | Tolerance p820 | doi:10.1038/nri2684 PDF Innate immunity: Coated for destruction in new defence strategy p821 | doi:10.1038/nri2672 PDF Macrophages: Self-renewing macrophages p822 | doi:10.1038/nri2678 PDF Tumour immunology: Inflammatory transformation p822 | doi:10.1038/nri2682 PDF Immunology JOBS of the week Research Associate University of Cambridge, Department of Pathology Cambridge United Kingdom Assistant or Associate Professor, Section of Anatomic Pathology The Medical College of Georgia Augusta, Georgia, USA Postdoctoral Associate / Research Associate Yale University School of Medicine New Haven, CT Research Associate Imperial College London London United Kingdom Postdoctoral Research Fellow Singapore Immunology Network (SIgN) Singapore More Science jobs from Immunology EVENT Cranfield Health's First Conference on Regenerative Medicine 22.-23.04.10 Cranfield, UK More science events from
REVIEWS		Top
Naive T cell homeostasis: from awareness of space to a sense of place Kensuke Takada & Stephen C. Jameson p823 | doi:10.1038/nri2657 This Review describes our current understanding of how the 'space' for the peripheral naive T cell pool is influenced by competition for homeostatic signals and how the 'place' at which the T cells encounter these signals can influence their physical and functional maintenance. Abstract | Full Text | PDF
Antigen presentation in the thymus for positive selection and central tolerance induction Ludger Klein, Maria Hinterberger, Gerald Wirnsberger & Bruno Kyewski p833 | doi:10.1038/nri2669 Recognition of self-peptide-MHC complexes in the thymus is necessary for thymocyte survival, but can also result in cell death. Here, the authors provide a unique insight into this apparent paradox, describing how the repertoire of self-peptide-MHC complexes that support T cell selection is shaped. Abstract | Full Text | PDF
Dysregulation of germinal centres in autoimmune disease Carola G. Vinuesa, Iñaki Sanz & Matthew C. Cook p845 | doi:10.1038/nri2637 Germinal centres are hubs for the generation of long-lived high-affinity antibodies that are necessary for adaptive immunity, but they can also be the source of pathogenic autoantibodies. Here, the authors explore how dysregulation of germinal centres might contribute to autoimmune disease. Abstract | Full Text | PDF | Supplementary information
Article series: Tissue-specific immune responses Tissue-mediated control of immunopathology in coeliac disease Bana Jabri & Ludvig M. Sollid p858 | doi:10.1038/nri2670 Coeliac disease results from an inappropriate response to dietary gluten. In this Review, the authors describe the ways in which intestinal tissue cells contribute to the inflammatory environment that leads to the induction of a tissue-destructive, gluten-specific T cell response. Abstract | Full Text | PDF
Endolysosomal proteases and their inhibitors in immunity Phillip I. Bird, Joseph A. Trapani & José A. Villadangos p871 | doi:10.1038/nri2671 This Review discusses the recent studies revealing new roles for endolysosomal proteases in immune cells, as well as their well known involvement in antigen presentation. These include crucial activities in innate immunity, regulation of cell death and control of pathogen invasion. Abstract | Full Text | PDF
PERSPECTIVES		Top
OPINION Interplay between the TH17 and TReg cell lineages: a (co-)evolutionary perspective Casey T. Weaver & Robin D. Hatton p883 | doi:10.1038/nri2660 These authors propose that the T helper 17 cell and induced regulatory T cell lineages were the first T cells of the adaptive immune system to evolve in vertebrates as a means to counter-regulate immune responses in the gut to foster a large, diverse commensal microbiota for the benefit of the host. Abstract | Full Text | PDF
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